A66

SKU: orb1305510

Description

A66

Research Area

Signal Transduction

Key Properties

• CAS Number: 1166227-08-2
• MW: 393.53
• Purity: 99.51%
• Formula: C₁₇H₂₃N₅O₂S₂
• SMILES: Cc1nc(NC(=O)N2CCC[C@H]2C(N)=O)sc1-c1csc(n1)C(C)(C)C
• Target: PI3K
• Solubility: Ethanol:1 mg/mL (2.54 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.08 mM);DMSO:60 mg/mL (152.47 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  p110α:32 nM|p110α-E545K:30 nM|p110γ:3480 nM|PI4Kβ:236 nM|PI3KC2β:462 nM|p110α-H1047R:43 nM
• In Vivo:
  A66 significantly inhibits the oncogenic forms of p110α, such as p110αE545K (IC50=30 nM) and p110αH1047R (IC50=43 nM), effectively reducing their activity.
• In Vitro:
  In male CD1 mice, A66 (10 mg/kg) increased glucose production during the pyruvate tolerance test. In SK-OV-3 tumor tissues, A66 (100 mg/kg) effectively reduced the phosphorylation of Akt/PKB and p70 S6 kinase, inhibiting tumor cell growth.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

A 66, A66, A-66, inhibit, Inhibitor, p110γ, p110α, p110δ, Phosphoinositide 3-kinase, PI3K, PI3Kβ

Compound Identifiers

PubChem CID

42636535