2-Furoic acid

SKU: orb1301707

Description

2-Furoic acid is a small molecule with reported anti-lipidemic properties, including the reduction of serum cholesterol and triglycerides. It serves as a research tool for metabolic studies in both in vitro assays and in vivo animal models of dyslipidemia.

Research Area

Infectious Disease & Virology, Metabolism Research

Key Properties

• CAS Number: 88-14-2
• MW: 112.08
• Purity: >99.99% (May vary between batches)
• Formula: C₅H₄O₃
• SMILES: OC(=O)C1=CC=CO1
• Target: Endogenous Metabolite,ATP Citrate Lyase,Anti-infection,Acyltransferase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (17.84 mM);DMSO:45 mg/mL (401.5 mM)

Bioactivity

• In Vivo:
  2-Furoic acid selectively inhibited bone resorbing activities of osteoclasts and prevented bone loss induced by estrogen deficiency but did not affect bone formation. 2-Furoic acid, an orally active selective human cathepsin K inhibitor, may have the therapeutic potential for the treatment of diseases characterized by excessive bone loss including osteoporosis.
• In Vitro:
  Agar that contains trace amounts of 5-HMFA and Furan-2-carboxylic acid inhibits the proliferation of some slow-growing or difficult-to-culture bacteria on the plates.
• Cell Research:
  The inhibitory effects of 5-HMFA, FA, and a mixture of the furan-2-carboxylic acids on the swarming and swimming of P. collierea V5-G'5 were assayed on MW solid medium (pH 6.0) containing 0.3% washed agar. The concentrations of these compounds were determined by the concentrations found in 0.3% agar plates (1×), and a series of two fold dilutions ranging from 0.125× to 8× was tested. As 5-HMFA and FA remained in the washed agar at concentrations of 0.07 and 0.12 μg g 1 agar, respectively, the 0.3% agar medium supplemented with 0.125× furan-2-carboxylic acids, contained 0.32 ng mL 1 and 0.51 ng mL 1 FA, respectively.
• Animal Research:
  When given orally twice daily for 4 weeks to 3-month-old ovariectomized (OVX) rats, Furan-2-carboxylic acid dose-dependently prevented bone loss, as monitored by bone densitometry, ash content, and urinary excretion of deoxypyridinoline. No change in serum osteocalcin in the OVX rats by Furan-2-carboxylic acid suggested that bone formation might not be affected by the agent.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Diacylglycerol acyltransferase, Diglyceride acyltransferase, Endogenous Metabolite, Antiinfection, Anti-infection, ATP Citrate Lyase, ATPCitrateLyase, 2 Furoic acid, 2Furoic acid, 2-Furoic acid, ACLY, Acyltransferase, acyl-CoA:cholesterol acyltransferase, inhibit, Furan-2-carboxylic acid, EndogenousMetabolite, Inhibitor, mono- acylglycerol acyltransferase

Compound Identifiers

PubChem CID

6919