You have no items in your shopping cart.
You have no items in your shopping cart.
Catalog Number | orb1823862 |
---|---|
Category | Antibodies |
Description | Recognizes a protein of 17-31kDa, identified as interleukin 1beta. It shows no cross-reaction with interleukin 1alpha. Epitopes of mAb IL1B/463 and IL1B/4650 are different and provide a good pair for developing an ELISA. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. |
Species/Host | Mouse |
Clonality | Monoclonal |
Clone Number | IL1B/4650 |
Tested applications | ELISA, IHC-P |
Reactivity | Human |
Isotype | Mouse IgG2b, kappa |
Immunogen | A recombinant partial protein sequence (within amino acids 100-269) from the human protein was used as the immunogen for the Interleukin-1 beta antibody. |
Dilution range | ELISA (Order BSA-free format for coating),Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT |
Conjugation | Unconjugated |
Formula | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide |
Hazard Information | This Interleukin-1 beta antibody is available for research use only. |
UniProt ID | P01584 |
Storage | Aliquot the Interleukin-1 beta antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles. |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
Filter by Rating