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IL-6R alpha/CD126 Protein, Human, Recombinant (His & Avi)
Catalog Number: orb1960598
| Catalog Number | orb1960598 |
|---|---|
| Category | Proteins |
| Description | The multifunctional factor interleukin 6 (IL-6) exerts its activities through binding to a high-affinity receptor complex consisting of two membrane glycoproteins: an 80 kDa component receptor that binds IL-6 with low affinity (IL-6R alpha) and a signal-transducing component of 130 kDa (gp130) that does not bind IL-6 by itself, but is required for high-affinity binding of IL-6 by the complex. Both components of the receptor complex, IL-6R alpha and gp130 have been cloned, sequenced, and expressed. |
| Tag | C-His-Avi |
| Purity | 98.00% |
| UniProt ID | P08887 |
| MW | 41.4 kDa (predicted). Due to glycosylation, the protein migrates to 65-78 kDa based on Tris-Bis PAGE result. |
| Application notes | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Expression System | HEK293 Cells |
| Biological Origin | Human |
| Biological Activity | The multifunctional factor interleukin 6 (IL-6) exerts its activities through binding to a high-affinity receptor complex consisting of two membrane glycoproteins: an 80 kDa component receptor that binds IL-6 with low affinity (IL-6R alpha) and a signal-transducing component of 130 kDa (gp130) that does not bind IL-6 by itself, but is required for high-affinity binding of IL-6 by the complex. Both components of the receptor complex, IL-6R alpha and gp130 have been cloned, sequenced, and expressed. |
| Expression Region | Leu20-Pro365 |
| Storage | -20°C |
| Note | For research use only |
