IL-18 Protein, Mouse, Recombinant (His)

Catalog Number: orb1961266

Catalog Number	orb1961266
Category	Small Molecules
Description	IL-18 Protein, Mouse, Recombinant (His)
Purity	98.00%
MW	20 KDa, reducing conditions
Biological Activity	Interleukin-18 (IL-18）is a protein which belongs to the IL-1 family. It is expressed as a 24 kDa precursor by endothelial and epithelial cells, keratinocytes, gamma δ T cells, and phagocytes. Mature mouse IL-18 shares 63% and 91% amino acid sequence identity with mouse and rat IL-18, respectively. IL-18 binds to the widely expressed IL-18 R alpha which recruits IL-18 R beta to form the signaling receptor complex. Its bioactivity is negatively regulated by interactions with IL-18 binding proteins and virally encoded IL-18BP homologs. It augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. In the presence of IL-12 or IL-15, IL-18 enhances anti-viral Th1 immune responses by inducing IFN-gamma production and the cytolytic activity of CD8+ T cells and NK cells. In the absence of IL-12 or IL-15, however, IL-18 promotes production of the Th2 cytokines IL-4 and IL-13 by CD4+ T cells and basophils.
Note	For research use only
Expiration Date	12 months from date of receipt.

Purity:	> 95% by SDS-PAGE.
Source:	KMP1653, Recombinant Mouse IL-18/IL-1F4 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Asn36-Ser192) of mouse IL-18/IL-1F4 (Accession #P70380) fused with an initial Met at the N-terminus and a 6×His Tag at the N-terminus.

Sizes Available: 50 μg, 500 μg

Purity:	≥90% as determined by SDS-PAGE
Source:	This protein contains the mouse Il18(Asn36-Ser192) was fused with the N-terminal His Tag and expressed in E. coli.