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IL-17 Protein, Mouse, Recombinant (His)
Catalog Number: orb1961161
| Catalog Number | orb1961161 |
|---|---|
| Category | Proteins |
| Description | Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. Mature mouse IL-17A shares 61% and 89% amino acid sequence identity with human and rat IL-17A, respectively. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation. |
| Tag | C-6xHis |
| Purity | > 99% |
| Protein Sequence | Thr22-Ala158 |
| UniProt ID | Q62386 |
| MW | 17-26 KDa (reducing condition) |
| Application notes | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Expression System | HEK293 Cells |
| Biological Origin | Mouse |
| Biological Activity | Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. Mature mouse IL-17A shares 61% and 89% amino acid sequence identity with human and rat IL-17A, respectively. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation. |
| Expression Region | Thr22-Ala158 |
| Storage | -20°C |
| Note | For research use only |
- Item 1 of 1
Recombinant mouse IL-17A protein, C-His-Avi (HEK293) [orb1516412]
> 95% as determined by Tris-Bis PAGE
Due to glycosylation, the protein migrates to 20-28 kDa based on Tris-Bis PAGE result.
50 μg, 10 μg - Item 1 of 1
Recombinant mouse IL17RB protein, C-His [orb1808141]
> 90% as determined by SDS-PAGE
30.7 kDa
100 μg, 500 μg Recombinant Mouse IL-17A Protein, His Tag [orb1551022]
> 95% by SDS-PAGE.
Recombinant Mouse IL-17A Protein is produced by Mammalian expression system. The target protein is expressed with sequence (Thr22-Ala158) of mouse IL-17A (Accession #Q62386) fused with a 6��His Tag at the C-terminus.
50 μgRecombinant Mouse IL17A Protein, N-His [orb2834020]
> 90% as determined by SDS-PAGE.
17.67 kDa
100 μg, 50 μg, 20 μgRecombinant Mouse IL17RE Protein, N-His [orb2831451]
> 90% as determined by SDS-PAGE.
32.95 kDa
100 μg, 50 μg, 20 μg
