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Catalog Number | orb1955676 |
---|---|
Category | Small Molecules |
Description | IL-15 Protein, Human, Recombinant (His) |
Purity | 98.00% |
MW | Approxiamtely 14.9 kDa |
Biological Activity | The protein encoded by the IL15 gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietic receptor subunits and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively, spliced transcript variants of this gene have been reported.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
> 95% by SDS-PAGE. | |
KMP1787, Recombinant human IL-15 Protein is produced by HEK293 Cells expression system. The target protein is expressed with sequence (Asn49-Ser162) of human IL-15 (Accession #NP_000576.1) fused with a Fc, 6×His Tag at the C-terminus. |
≥90% as determined by SDS-PAGE | |
This protein contains the human IL15(Asn49-Ser162) was fused with the C-terminal His Tag and expressed in E. coli. |
> 95% by SDS-PAGE. | |
KMP1368, Recombinant human IL-15 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Asn49-Ser162) of human IL-15 (Accession #NP_000576.1) fused with a 6×His Tag at the C-terminus. |
> 95% by SDS-PAGE. | |
KMP1328, Recombinant human IL-15R alpha/CD215 Protein is produced by HEK293 Cells expression system. The target protein is expressed with sequence (Met1-Thr205) of human IL-15R alpha/CD215 (Accession #NP_002180.1) fused with a Fc, 6×His Tag at the C-terminus. |
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