IDE Protein, Human, Recombinant (His)

Catalog Number: orb1961455

Catalog Number	orb1961455
Category	Small Molecules
Description	IDE Protein, Human, Recombinant (His)
Purity	98.00%
MW	120 KDa, reducing conditions
Biological Activity	Insulin-Degrading Enzyme (IDE) is a secreted enzyme that belongs to the peptidase M16 family. IDE is a large zinc-binding protease and cleaves multiple short polypeptides that vary considerably in sequence. IDE plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin, and other peptides, and thereby plays a role in intercellular peptide signaling. IDE degrades amyloid formed by APP and IAPP. IDE may participate in the degradation and clearance of naturally secreted amyloid β-protein by neurons and microglia. IDE, which migrates at 110 kDa during gel electrophoresis under denaturing conditions, has since been shown to have additional substrates, including the signaling peptides glucagon, TGF α and β-endorphin.
Note	For research use only
Expiration Date	12 months from date of receipt.

Recombinant Human IDE Protein, His Tag [orb1552234]
Purity:
≥90% as determined by SDS-PAGE
Source:
This protein contains the human IDE(Met42-Leu1019) was fused with the C-terminal His Tag and expressed in Mammalian cells.
Sizes Available: 100 μg, 50 μg
Human IDE protein (C-His) [orb311815]
Source:
Human Cells
Sizes Available: 1 mg, 500 μg, 50 μg, 10 μg

Purity:	≥90% as determined by SDS-PAGE
Source:	This protein contains the human IDE(Met42-Leu1019) was fused with the C-terminal His Tag and expressed in Mammalian cells.