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IC-8

Catalog Number: orb1785882

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$ 610.00
Catalog Numberorb1785882
CategorySmall Molecules
DescriptionIC8 is an ionizable cationic lipid. It has been used in combination with other lipids for the formation of lipid nanoparticles (LNPs). Immunization with severe acute respiratory coronavirus 2 (SARS-CoV-2) spike glycoprotein mRNA in IC8- and manganese-containing LNPs induces IgG responses to SARS-CoV-2 Delta and Omicron variants in mice.1 Administration of mRNA encoding B7-H3 X CD3 bispecific T cell engaging (BiTE) antibodies in IC8-containing LNPs reduces tumor growth in MV4-11 and A375 mouse xenograft models.
MW1049.8
CAS Number[2349307-32-8]
FormulaC66H136N4O4
SMILESOC(CCCCCCCCCCCC)CN(CC(CCCCCCCCCCCC)O)CCCN1CCN(CCCN(CC(CCCCCCCCCCCC)O)CC(CCCCCCCCCCCC)O)CC1
NoteFor research use only
IC-8

Chemical structure of orb1785882