IC-8

• Catalog Number: orb1785882
• Category: Small Molecules
• Description: IC8 is an ionizable cationic lipid. It has been used in combination with other lipids for the formation of lipid nanoparticles (LNPs). Immunization with severe acute respiratory coronavirus 2 (SARS-CoV-2) spike glycoprotein mRNA in IC8- and manganese-containing LNPs induces IgG responses to SARS-CoV-2 Delta and Omicron variants in mice.1 Administration of mRNA encoding B7-H3 X CD3 bispecific T cell engaging (BiTE) antibodies in IC8-containing LNPs reduces tumor growth in MV4-11 and A375 mouse xenograft models.
• MW: 1049.8
• CAS Number: [2349307-32-8]
• Formula: C₆₆H₁₃₆N₄O₄
• SMILES: OC(CCCCCCCCCCCC)CN(CC(CCCCCCCCCCCC)O)CCCN1CCN(CCCN(CC(CCCCCCCCCCCC)O)CC(CCCCCCCCCCCC)O)CC1
• Note: For research use only

Chemical structure of orb1785882