Hydroxychloroquine sulfate

SKU: orb1310137

Description

Hydroxychloroquine sulfate is a research compound that acts as an antimalarial by inhibiting plasmodial heme polymerase within the parasite's food vacuole. It is widely used in parasitology and immunology research, including in vitro studies of Plasmodium falciparum and in vivo models of autoimmune diseases.

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Molecular Biology

Key Properties

• CAS Number: 747-36-4
• MW: 433.95
• Purity: 99.88% (May vary between batches)
• Formula: C₁₈H₂₆ClN₃O·H₂SO₄
• SMILES: OS(=O)(=O)O.CCN(CCO)CCCC(C)Nc1c2ccc(Cl)cc2ncc1
• Target: SARS-CoV,Parasite,DNA,TLR,Autophagy
• Solubility: DMSO:Insoluble;H2O:10 mM

Bioactivity

• In Vivo:
  The treatment of Hydroxychloroquine Sulfate reduces the infarct size in an in vivo rat model of I/R injury and the cardioprotective effect of Hydroxychloroquine is ERK1/2 dependent. In addition, Hydroxychloroquine Sulfate shows an early vascular protective effect. HCQ seems to prevent the occurrence of endothelial dysfunction(ED) in treated animals.
• In Vitro:
  Hydroxychloroquine Sulfate is a potent inhibitor of autophagy. It prevents lysosomal acidification, thereby interfering with a key step in the autophagic process.HCQ treatment inhibits RCC (renal cell cancer) cell growth, promotes apoptosis, inhibits mitochondrial oxygen consumption, and increases rates of glycolysis.
• Cell Research:
  All cells are cultured in RPMI with 10% FBS, 1% glutamine, and 1% Pen/Strep. cells are seeded on the appropriated plates overnight and treated with HCQ (75 or 100 μM) for 48 hours.(Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SARS coronavirus, SARSCoV, SARS-CoV, TLR9, TLR, Toll-like Receptor (TLR), Autophagy, Acidum iopanoicum, DNA, Inhibitor, inhibit, Parasite, Hydroxychloroquine, Hydroxychloroquine sulfate, Hydroxychloroquine Sulfate, HCQ, HCQ sulfate, HCQ Sulfate

Compound Identifiers

PubChem CID

12947