Human TWEAK R / TNFRSF12A Protein

• Catalog Number: orb257884
• Category: Proteins
• Description: Tumor necrosis factor receptor superfamily member 12A (TNFRSF12A) is also known as Fibroblast growth factor-inducible immediate-early response protein 14 (FN14 or FGF-inducible 14), Tweak-receptor, CD antigen CD266. TNFRSF12A contains one TNFR-Cys repeat. TNFRSF12A is highly expressed in heart, placenta and kidney. TNFRSF12A is receptor for TNFSF12/TWEAK, and is weak inducer of apoptosis in some cell types. TNFRSF12A / FN14 promotes angiogenesis and the proliferation of endothelial cells.
• Reactivity: Human
• Tag: N-Fc
• Form/Appearance: Powder
• Purity: 95%
• Conjugation: Unconjugated
• MW: 32.5 kDa
• Target: TWEAK R
• Protein Sequence: AAH02718
• Source: Human TWEAK R, Fc Tag (orb257884) is expressed from human 293 cells (HEK293). It contains AA Glu 28 - Trp 79 (Accession # AAH02718).
• Expression System: HEK293
• Expression Region: Glu 28 - Trp 79
• Endotoxins: 1.0 EU per μg
• NCBI: AAH02718
• Storage: -20°C
• Buffer/Preservatives: 50 mM Tris, 100 mM Glycine, pH7.5
• Alternative names: TNFRSF12A,FGF-inducible 14,FN14,TweakR,CD266
• Note: For research use only
• Application notes: This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 32.5 kDa. As a result of glycosylation, the protein migrates as 32-45 kDa under reducing (R) condition, and 55-80 kDa under non-reducing (NR) condition (SDS-PAGE).
• Expiration Date: 6 months from date of receipt.

SDS-PAGE analysis of Human TWEAK R protein