Human Transthyretin / Prealbumin Protein

• Catalog Number: orb257905
• Category: Proteins
• Description: Transthyretin (TTR) is also known as Prealbumin, ATTR, TBPA, PALB, which belongs to the transthyretin family. Transthyretin / TTR is a serum and cerebrospinal fluid carrier of the thyroid hormone thyroxine (T4) and retinol-binding protein bound to retinol. In cerebrospinal fluid TTR is the primary carrier of T4. TTR also acts as a carrier of retinol (vitamin A) through its association with retinol-binding protein (RBP) in the blood and the CSF. Less than 1% of TTR's T4 binding sites are occupied in blood. TTR misfolding and aggregation is known to be associated with the amyloid diseases.
• Reactivity: Human
• Tag: C-8×His
• Form/Appearance: Powder
• Purity: 95%
• Conjugation: Unconjugated
• MW: 14.9 kDa
• Target: Transthyretin
• Protein Sequence: NP_000362
• Source: Human Transthyretin, His Tag (orb257905) is expressed from human 293 cells (HEK293). It contains AA Gly 21 - Glu 147 (Accession # NP_000362).
• Expression System: HEK293
• Expression Region: Gly 21 - Glu 147
• Endotoxins: 1.0 EU per μg
• NCBI: NP_000362
• Storage: -20℃
• Buffer/Preservatives: PBS, pH7.4
• Alternative names: Transthyretin,TTR,Prealbumin,TBPA,ATTR,PALB,CTS,CT
• Note: For research use only
• Application notes: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 14.9 kDa. The protein migrates as 17 kDa and 33 kDa under reducing (R) condition (SDS-PAGE) due to the monomer and dimer respectively.
• Expiration Date: 6 months from date of receipt.

SDS-PAGE analysis of Human Transthyretin protein