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| Catalog Number | orb257896 |
|---|---|
| Category | Proteins |
| Description | Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) is also known as TNF-related apoptosis-inducing ligand receptor 1 (TRAIL-R1), Death receptor 4 (DR4), CD261 and APO2, which belongs to TNF superfamily. TRAILR1 / TNFRSF10A contains 1 death domain and 3 TNFR-Cys repeats. TNFRSF10A / DR4 is widely expressed and high levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells. APO2 / TNFRSF10A is receptor for the cytotoxic ligand TNFSF10 / TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TRAILR-1 / DR4 / CD261 promotes the activation of NF-kappa-B. |
| Reactivity | Human |
| Tag | C-Fc |
| Form/Appearance | Powder |
| Purity | 95% |
| Conjugation | Unconjugated |
| MW | 49.0 kDa |
| Target | TRAIL R1 |
| Protein Sequence | NP_003835 |
| Source | Human TRAIL R1, Fc Tag (orb257896) is expressed from human 293 cells (HEK293). It contains AA Ala 24 - Asn 239 (Accession # NP_003835). |
| Expression System | HEK293 |
| Expression Region | Ala 24 - Asn 239 |
| Endotoxins | 1.0 EU per μg |
| NCBI | NP_003835 |
| Storage | -20℃ |
| Buffer/Preservatives | 50 mM Tris, 100 mM Glycine, pH7.5 |
| Alternative names | TNFRSF10A,TRAIL-R1,CD261,APO2,DR4 Read more... |
| Note | For research use only |
| Application notes | This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 49.0 kDa. The protein migrates as 45-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
| Expiration Date | 6 months from date of receipt. |
Mettler Izquierdo, Shelley et al. High-efficiency antibody discovery achieved with multiplexed microscopy Microscopy (Oxf), 65, 341-352 (2016)
SDS-PAGE analysis of Human TRAIL R1 protein
- Item 1 of 1
Human TRAIL R1 / DR4 / TNFRSF10A Protein [orb257894]
Unconjugated
90%
24.8 kDa
Human TRAIL R1, His Tag (orb257894) is expressed from human 293 cells (HEK293). It contains AA Ala 24 - Asn 239 (Accession # O00220-1).
1 mg, 100 μg 
Biotinylated Recombinant Human TRAIL R1 / DR4 / TNFRSF10A Protein, Avi His Tag [orb1550348]
> 95% by Tris-Bis PAGE, > 95% by SEC-HPLC
KMP2141, Biotinylated Recombinant Human TRAIL R1 / DR4 / TNFRSF10A Protein is produced by Expi293 expression system. The target protein is expressed with sequence (Pro34-Asn239) of Human TRAIL R1 / DR4 / TNFRSF10A fused with His Tag and Avi tag at the C-terminal.
500 μg, 100 μgRecombinant Human TRAIL R1 / DR4 / TNFRSF10A Protein, Avi His Tag [orb1550365]
> 95% by Tris-Bis PAGE, > 95% by SEC-HPLC
KMP2124, Recombinant Human TRAIL R1 / DR4 / TNFRSF10A Protein is produced by Expi293 expression system. The target protein is expressed with sequence (Pro34-Asn239) of Human TRAIL R1 / DR4 / TNFRSF10A fused with His Tag and Avi tag at the C-terminal.
100 μg, 500 μg
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