Human TNFR1 / CD120a / TNFRSF1A Protein

• Catalog Number: orb257876
• Category: Proteins
• Description: Tumor necrosis factor receptor 1 (TNF-R1) is also known as Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A), TNFAR, CD antigen CD120a, which belongs to the tumor necrosis factor receptor superfamily. TNF-R1 contains one death domain and four TNFR-Cys repeats. TNF-R1 is the receptor of TNFSF2 / TNF-alpha and homotrimeric TNFSF1 / lymphotoxin - alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TNF-R1 contributes to the induction of non - cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. Defects in TNFRSF1A are the cause of familial hibernian fever (FHF).
• Reactivity: Human
• Tag: C-8×His
• Form/Appearance: Powder
• Purity: 90%
• Conjugation: Unconjugated
• MW: 22.3 kDa
• Target: TNFR1
• Protein Sequence: NP_001056
• Source: Human TNFR1, His Tag (orb257876) is expressed from human 293 cells (HEK293). It contains AA Ile 22 - Thr 211 (Accession # NP_001056).
• Expression System: HEK293
• Expression Region: Ile 22 - Thr 211
• Endotoxins: 1.0 EU per μg
• NCBI: NP_001056
• Storage: -20℃
• Buffer/Preservatives: PBS, pH7.4
• Alternative names: TNFR1,CD120a,TNFRSF1A,FPF,TBP1,TNF-R,TNF-R-I,TNF-R
• Note: For research use only
• Application notes: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 22.3 kDa. The protein migrates as 28-40 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to different glycosylation.
• Expiration Date: 6 months from date of receipt.

SDS-PAGE analysis of Human TNFR1 protein