Human TGF-beta 3 / TGFB3 Protein

• Catalog Number: orb762421
• Category: Proteins
• Description: Transforming growth factor beta 3 ( TGFB3) is also known as TGF-β3, is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development. TGF-beta 3 is similar with TGF-beta 1 and ­-beta 2, act as cellular switches to regulate immune function, cell proliferation, and epithelial­-mesenchymal transition. TGF-beta-3 is released from LAP by integrins: integrin-binding results in distortion of the LAP chain and subsequent release of the active TGF-beta-3. Once activated following release of LAP, TGF-beta-3 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal.
• Reactivity: Human
• Tag: Native
• Form/Appearance: Powder
• Purity: 95%
• Conjugation: Unconjugated
• MW: 12.7 kDa
• Target: TGF-beta 3
• Protein Sequence: NP_003230.1
• Source: Human TGF-beta 3, Tag Free (orb762421) is expressed from human 293 cells (HEK293). It contains AA Ala 301 - Ser 412 (Accession # P10600-1).
• Expression System: HEK293
• Expression Region: Ala 301 - Ser 412
• Endotoxins: 1.0 EU per μg
• NCBI: NP_003230.1
• Storage: -20°C
• Buffer/Preservatives: 50 mM HAC, pH3.2
• Alternative names: TGFB3,ARVD,TGF-beta3
• Note: For research use only
• Application notes: This protein carries no "tag". The protein has a calculated MW of 12.7 kDa. The protein migrates as 12 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).
• Expiration Date: 6 months from date of receipt.