Human TFPI-2 Protein

• Catalog Number: orb257862
• Category: Proteins
• Description: Tissue Factor Pathway Inhibitor 2 (TFPI­2) is also known as placental protein 5 (PP5) and retinal pigment epithelial cell factor 1 (REF­1), is a member of the Kunitz-type serine proteinase inhibitor family, is a structural homologue of tissue factor pathway inhibitor (TFPI). TFPI2 is highly abundant in the full-term placenta and widely expressed in umbilical vein endothelial cells, liver, placenta, heart, pancreas, and maternal serum at advanced pregnancy. TFPI­2 may play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa and has no effect on thrombin. Reduced synthesis of TFPI-2 has been related to numerous pathophysiological processes such as inflammation, angiogenesis, atherosclerosis, retinal degeneration and tumor growth / metastasis.
• Reactivity: Human
• Tag: C-6×His
• Form/Appearance: Powder
• Purity: 95%
• Conjugation: Unconjugated
• MW: 22.7 kDa
• Target: TFPI-2
• Protein Sequence: NP_006519.1
• Source: Human TFPI-2, His Tag (orb257862) is expressed from human 293 cells (HEK293). It contains AA Asp 23 - Lys 213 (Accession # NP_006519.1).
• Expression System: HEK293
• Expression Region: Asp 23 - Lys 213
• Endotoxins: 1.0 EU per μg
• NCBI: NP_006519.1
• Storage: -20℃
• Buffer/Preservatives: PBS, pH7.4
• Alternative names: TFPI2,PP5,REF1
• Note: For research use only
• Application notes: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 22.7 kDa. The protein migrates as 26-32 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.

SDS-PAGE analysis of Human TFPI-2 protein