Human Stathmin 1 / STMN1 Protein

• Catalog Number: orb257855
• Category: Proteins
• Description: Stathmin (STMN1), a member of the stathmin family, is also known as Leukemia-associated phosphoprotein p18, Oncoprotein 18 (Op18), Phosphoprotein p19 (pp19), Protein Pr22 and pp17, which contains one SLD (stathmin-like) domain. The function of STMN1 as an important regulatory protein of microtubule dynamics has been well-characterized. Stathmin (STMN1) interacts with two molecules of dimeric α,β-tubulin to form a tight ternary complex called the T2S complex.One mole of STMN1 binds to two moles of tubulin dimers through the stathmin-like domain (SLD).When STMN1 sequesters tubulin into the T2S complex, tubulin becomes non-polymerizable. Without tubulin polymerization, there is no microtubule assembly.STMN1 also promotes microtubule disassembly by acting directly on the microtubule ends.
• Reactivity: Human
• Tag: N-6×His
• Form/Appearance: Powder
• Purity: 95%
• Conjugation: Unconjugated
• MW: 18.1 kDa
• Target: Stathmin 1
• Protein Sequence: NP_981946
• Source: Human Stathmin 1, His Tag (orb257855) is expressed from E.coli cells. It contains AA Ala 2 - Asp 149 (Accession # NP_981946).
• Expression System: E. coli
• Expression Region: Ala 2 - Asp 149
• Endotoxins: 1.0 EU per μg
• NCBI: NP_981946
• Storage: -20℃
• Buffer/Preservatives: PBS, pH7.4
• Alternative names: STMN1,Stathmin,C1orf215,LAP18,OP18
• Note: For research use only
• Application notes: This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 18.1 kDa. The protein migrates as 18 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).
• Expiration Date: 6 months from date of receipt.

SDS-PAGE analysis of Human Stathmin 1 protein