Human Siglec-6 / CD327 Protein

• Catalog Number: orb257841
• Category: Proteins
• Description: Sialic acid-binding Ig-like lectin 6 (SIGLEC6) is also known as CD antigen CD327, CD33 antigen-like 1 (CD33L or CD33L1), Obesity-binding protein 1 (OB-BP1). SIGLEC6 belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family, which contains two Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. SIGLEC6 mediates sialic-acid dependent binding to cells. SIGLEC6 binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
• Reactivity: Human
• Tag: C-Fc
• Form/Appearance: Powder
• Purity: 95%
• Conjugation: Unconjugated
• MW: 60.3 kDa
• Target: Siglec-6
• Protein Sequence: AAH35359
• Source: Human Siglec-6, Fc Tag (orb257841) is expressed from human 293 cells (HEK293). It contains AA Gln 16 - Val 320 (Accession # AAH35359).
• Expression System: HEK293
• Expression Region: Gln 16 - Val 320
• Endotoxins: 1.0 EU per μg
• NCBI: AAH35359
• Storage: -20℃
• Buffer/Preservatives: 50 mM Tris, 100 mM Glycine, 150 mM NaCl, pH7.5
• Alternative names: SIGLEC6,CD327,CD33L,CD33L1,OBBP1,OB-BP1,CDw327
• Note: For research use only
• Application notes: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 60.3 kDa. As a result of glycosylation, the protein migrates as 80-100 kDa under reducing (R) condition, and 130-150 kDa and 250-300 kDa under non-reducing (NR) condition (SDS-PAGE).
• Expiration Date: 6 months from date of receipt.

SDS-PAGE analysis of Human Siglec-6 protein