Human Siglec-10 Protein

More Information
Category	Proteins
Catalog Number	orb511226
Reactivity	Human
Conjugation	Unconjugated
MW	85.6 kDa
Target	Siglec-10
Protein Sequence	NP_149121.2
Tag	C-mFc(mIgG2a)
Source	Human Siglec-10, Mouse IgG2a Fc Tag, low endotoxin (SI0-H525b) is expressed from human 293 cells (HEK293). It contains AA Met 17 - Thr 546 (Accession # Q96LC7-1).
Biological origin	Human
Storage	-20℃
Purity	95%
Form/Appearance	Powder
Buffer/Preservatives	Tris with Glycine, Arginine and NaCl, pH7.5
Endotoxin	0.1 EU per μg
Note	For research use only.
Expiration Date	6 months from date of receipt.
Description	The siglecs (sialic acid-binding Ig-like lectins) are a distinct subset of the Ig superfamily with adhesion-molecule-like structure. We describe here a novel member of the siglec protein family that shares a similar structure including five Ig-like domains, a transmembrane domain, and a cytoplasmic tail containing two ITIM-signaling motifs. Siglec-10 was identified through database mining of an asthmatic eosinophil EST library. The Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products.

Tested applications:	ELISA, WB
Reactivity:	Canine, Human, Mouse, Porcine, Rat
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated