Human Siglec-10 Protein

• Catalog Number: orb511226
• Category: Proteins
• Description: The siglecs (sialic acid-binding Ig-like lectins) are a distinct subset of the Ig superfamily with adhesion-molecule-like structure. We describe here a novel member of the siglec protein family that shares a similar structure including five Ig-like domains, a transmembrane domain, and a cytoplasmic tail containing two ITIM-signaling motifs. Siglec-10 was identified through database mining of an asthmatic eosinophil EST library. The Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products.
• Reactivity: Human
• Tag: C-mFc(mIgG2a)
• Form/Appearance: Powder
• Purity: 95%
• Conjugation: Unconjugated
• MW: 85.6 kDa
• Target: Siglec-10
• Protein Sequence: NP_149121.2
• Source: Human Siglec-10, Mouse IgG2a Fc Tag, low endotoxin (orb511226) is expressed from human 293 cells (HEK293). It contains AA Met 17 - Thr 546 (Accession # Q96LC7-1).
• Expression System: HEK293
• Expression Region: Met 17 - Thr 546
• Endotoxins: 0.1 EU per μg
• NCBI: NP_149121.2
• Storage: -20℃
• Buffer/Preservatives: Tris with Glycine, Arginine and NaCl, pH7.5
• Alternative names: SIGLEC10,MGC126774,PRO940,Siglec10,SLG2
• Note: For research use only
• Application notes: This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 85.6 kDa. The protein migrates as 90-120 KDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.