Human sFasR protein

• Catalog Number: orb107710
• Category: Proteins
• Description: Fas and Fas Ligand (FasL) belong to the TNF superfamily and are type I and type II transmembrane proteins, respectively.Binding of FasL to Fas triggers apoptosis in Fas-bearing cells. The mechanism of apoptosis involves recruitment of pro-caspase 8through an adaptor molecule called FADD followed by processing of the pro-enzyme to active forms. These active caspases thencleave various cellular substrates leading to the eventual cell death. sFasR is capable of inhibiting FasL-induced apoptosis byacting as a decoy receptor that serves as a sink for FasL
• Tested applications: HPLC, SDS-PAGE
• Purity: > 95% by SDS-PAGE and HPLC analyses
• Conjugation: Unconjugated
• MW: 17.6 kDa
• Target: sFasR
• Protein Sequence: RLSSKSVNAQ VTDINSKGLE LRKTVTTVET QNLEGLHHDG QFCHKPCPPG ERKARDCTVNGDEPDCVPCQ EGKEYTDKAH FSSKCRRCRL CDEGHGLEVE INCTRTQNTK CRCKPNFFCNSTVCEHCDPC TKCEHGIIKE CTLTSNTKCK EEGSRSN
• Storage: Store at 4°C for up to two weeks. For long term storage, aliquot and store at -20°C, avoid freeze/thaw cycles.
• Buffer/Preservatives: Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.
• Note: For research use only
• Expiration Date: 6 months from date of receipt.

SDS-PAGE analysis of Human sFasR protein