Human Serpin F1 / PEDF Protein

• Catalog Number: orb257828
• Category: Proteins
• Description: erpin F1 (SERPINF1) is also known as Pigment epithelium-derived factor (PEDF), Cell proliferation-inducing gene 35 protein (PIG35). Serpin F1 belongs to the serpin family. Serpin F1 is expressed in quiescent cells. PEDF has a variety of functions including antiangiogenic, antitumorigenic, and neurotrophic properties. Endothelial cell migration is inhibited by SERPINF1/ PEDF. PEDF / SERPINF1 suppresses retinal neovascularization and endothelial cell proliferation. PEDF is also responsible for apoptosis of endothelial cells either through the p38 MAPK pathway or through the FAS/FASL pathway. PEDF also displays neurotrophic functions.
• Reactivity: Human
• Tag: C-6×His
• Form/Appearance: Powder
• Purity: 95%
• Conjugation: Unconjugated
• MW: 45.2 kDa
• Target: Serpin F1
• Protein Sequence: NP_002606
• Source: Human Serpin F1, His Tag (orb257828) is expressed from human 293 cells (HEK293). It contains AA Gln 20 - Pro 418 (Accession # NP_002606).
• Expression System: HEK293
• Expression Region: Gln 20 - Pro 418
• Endotoxins: 1.0 EU per μg
• NCBI: NP_002606
• Storage: -20℃
• Buffer/Preservatives: PBS, pH7.4
• Alternative names: SERPINF1,Serpin F1,PEDF,PIG35,EPC-1
• Note: For research use only
• Application notes: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 45.2 kDa. The protein migrates as 45-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.

SDS-PAGE analysis of Human PEDF protein