Human Serpin E2 / PN1 Protein

• Catalog Number: orb257832
• Category: Proteins
• Description: SERPINE2 is also known as Glia-derived nexin (GDN), Peptidase inhibitor 7 (PI7), Protease nexin 1(PN1). SERPINE2 is a secreted glycoprotein which belongs to the serpin family. SerpinE1 is the primary physiological inhibitor of the two plasminogen activators urokinase (uPA) and tissue plasminogen activator (tPA). PAI-1 / GDN is also implicated in adipose tissue development. It suggests that PAI-1 inhibitors serve in the control of atherothrombosis. Defects in Serpin E1 / PN1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency) which is characterized by abnormal bleeding due to SerpinE1 defect in the plasma.
• Reactivity: Human
• Tag: C-7×His
• Form/Appearance: Powder
• Purity: 90%
• Conjugation: Unconjugated
• MW: 42.8 kDa
• Target: Serpin E2
• Protein Sequence: Ser 20 - Pro 397
• Source: Human Serpin E2, His Tag (orb257832) is expressed from human 293 cells (HEK293). It contains AA Ser 20 - Pro 397 (Accession # P07093-2).
• Expression System: HEK293
• Expression Region: Ser 20 - Pro 397
• Endotoxins: 1.0 EU per μg
• Storage: -20℃
• Buffer/Preservatives: 20 mM Sodium Acetate, 100 mM NaCl, pH6.5
• Alternative names: SERPINE2,Glia-derived nexin,GDN,Peptidase inhibito
• Note: For research use only
• Application notes: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 42.8 kDa. The protein migrates as 48-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.

SDS-PAGE analysis of Human Serpin E2 protein