Human Serpin D1 / Heparin Cofactor II Protein

• Catalog Number: orb257535
• Category: Proteins
• Description: Serpin D1 is also known as Heparin cofactor 2 (HCF2), Protease inhibitor leuserpin-2 (HLS2), Heparin cofactor II (HC-II), which belongs to the serpin family. HCF2 is expressed predominantly in liver. Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, SerpinD1 / HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). In a glycosaminoglycan-independent manner, serpinD1 / HC-II also inhibits chymotrypsin. Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils.
• Reactivity: Human
• Tag: C-6×His
• Form/Appearance: Powder
• Purity: 95%
• Conjugation: Unconjugated
• MW: 55.7 kDa
• Target: Serpin D1
• Protein Sequence: AAH35028
• Source: Human Serpin D1, His Tag (orb257535) is expressed from human 293 cells (HEK293). It contains AA Gly 20 - Ser 499 (Accession # AAH35028).
• Expression System: HEK293
• Expression Region: Gly 20 - Ser 499
• Endotoxins: 1.0 EU per μg
• NCBI: AAH35028
• Storage: -20℃
• Buffer/Preservatives: 50 mM Tris, 150 mM NaCl, pH 7.5
• Alternative names: SerpinD1,HCF2,HLS2,HC-II
• Note: For research use only
• Application notes: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 55.7 kDa. The protein migrates as 66-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.

SDS-PAGE analysis of Human Serpin D1 protein