Human SDF-1 / CXCL12 Protein

• Catalog Number: orb864213
• Category: Proteins
• Description: Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Stimulates the proliferation of bone marrow-derived B-cell progenitors in the presence of IL7 as well as growth of stromal cell-dependent pre-B-cells
• Reactivity: Human
• Tag: N-10×His
• Form/Appearance: Powder
• Purity: 95%
• Conjugation: Unconjugated
• MW: 10.0 kDa
• Target: SDF-1
• Source: Human SDF-1, His Tag (orb864213) is expressed from E. coli cells. It contains AA Lys 22 - Lys 89 (Accession # P48061-2).
• Expression System: E. coli
• Expression Region: Lys 22 - Lys 89
• Endotoxins: 1.0 EU per μg
• NCBI: NP_954637.1
• Storage: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
• Buffer/Preservatives: PBS, pH7.4
• Alternative names: SDF-1,CXCL12,hSDF-1,IRH,hIRH,PBSF,SDF1,SDF1A,SDF1B
• Note: For research use only
• Application notes: This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 10.0 kDa. The protein migrates as 13 kDa under reducing (R) condition (SDS-PAGE).
• Expiration Date: 6 months from date of receipt.