Human PSME3 / PA28g Protein

Catalog Number: orb334921

Catalog Number	orb334921
Category	Proteins
Description	Proteasome activator complex subunit 3 (PSME3),a member of the PA28 family, is also known as 11S regulator complex subunit gamma (REG-gamma), activator of multicatalytic protease subunit 3 and proteasome activator 28 subunit gamma (PA28gamma). PSME3 activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. PSME3 can also facilitate the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. Furthermore,PSME3 may also be involved in cell cycle regulation.
Reactivity	Human
Tag	N-6×His
Form/Appearance	Powder
Purity	95%
Conjugation	Unconjugated
MW	30.3 kDa
Target	PSME3
Protein Sequence	NP_005780.2
Source	Human PSME3, His Tag (orb334921) is expressed from E.coli cells. It contains AA Ala 2 - Tyr 254 (Accession # P61289-1).
Expression System	E. coli
Expression Region	Ala 2 - Tyr 254
Endotoxins	1.0 EU per μg
NCBI	NP_005780.2
Storage	-20℃
Buffer/Preservatives	50 mM Tris, 150 mM NaCl, pH7.5
Alternative names	PSME3,PA28gamma,REG-gamma Read more...
Note	For research use only
Application notes	This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 30.3 kDa. The protein migrates as 28-33 kDa under reducing (R) condition (SDS-PAGE).
Expiration Date	6 months from date of receipt.

SDS-PAGE analysis of Human PSME3 protein