Human Pleiotrophin / PTN Protein, His Tag, premium grade

• Catalog Number: orb1786205
• Category: Proteins
• Description: Pleiotrophin and Midkine are structurally related heparin-binding neurotrophic factors, whose expression is developmentally regulated. The expression pattern of these neurotrophic factors suggests function in neurogenesis, cell migration, secondary organogenetic induction, and mesoderm epithelial interaction. The expression of PTN increases during the process of brain embryogenesis, and reaches maximum levels at time of birth. The physiological roles of PTN and Midkine are largely unknown, but these neurotrophins have been implicated in the pathogenesis of neuroblastomas. Recombinant Human Pleiotrophin is a 15.4 kDa protein containing 136 amino acid residues and five intra-molecular disulfide bonds.
• Reactivity: Human
• Tag: N-10×His
• Form/Appearance: Powder
• Purity: 95%
• Conjugation: Unconjugated
• MW: 17.2 kDa
• Target: Pleiotrophin
• Source: Human Pleiotrophin Protein, His Tag, premium grade (orb1786205) is expressed from human 293 cells (HEK293). It contains AA Gly 33 - Asp 168 (Accession # P21246).
• Expression System: E. coli
• Expression Region: Gly 33 - Asp 168
• Endotoxins: 0.1 EU per μg
• Storage: -20°C
• Buffer/Preservatives: PBS, pH 7.4
• Note: For research use only
• Application notes: This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 17.2 kDa. The protein migrates as 22-23 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.