Human pIgR Protein

• Catalog Number: orb257776
• Category: Proteins
• Description: Polymeric immunoglobulin receptor (PIGR) is also known as Poly-Ig receptor, which can be cleaved into membrane secretory component (SC). PIGR is a type I transmembrane glycoprotein or a member of the immunoglobulin superfamily, and is synthesized by secretory epithelial cells and delivered to the basolateral plasma membrane where it can bind larger polymers of IgA (pIgA ) and pentameric IgM. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.
• Reactivity: Human
• Tag: C-6×His
• Form/Appearance: Powder
• Purity: 95%
• Conjugation: Unconjugated
• MW: 68.7 kDa
• Target: pIgR
• Protein Sequence: AAI10495.1
• Source: Human pIgR, His Tag (orb257776) is expressed from human 293 cells (HEK293). It contains AA Lys 19 - Arg 638 (Accession # AAI10495.1).
• Expression System: HEK293
• Expression Region: Lys 19 - Arg 638
• Endotoxins: 1.0 EU per μg
• NCBI: AAI10495.1
• Storage: -20℃
• Buffer/Preservatives: PBS, pH7.4
• Alternative names: PIGR,Poly-Ig receptor
• Note: For research use only
• Application notes: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 68.7 kDa. The protein migrates as 90-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.

SDS-PAGE analysis of Human pIgR protein