Human NME1 / NDKA / NM23-H1 Protein

• Catalog Number: orb257714
• Category: Proteins
• Description: Nucleoside diphosphate kinase A, a member of the NDK family, is also known as NME1, NDP kinase A (NDPA), granzyme A-activated DNase (GAAD), metastasis inhibition factor nm23 (NM23-H1) and tumor metastatic process-associated protein. NME1 plays a major role in the synthesis of nucleoside triphosphates other than ATP. NME1 is also involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Furthermore, NME1 is required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, NME1 works in concert with TREX1. NME1 nicks one strand of D and TREX1 removes bases from the free 3' end to enhance D damage and prevent D end reannealing and rapid repair.
• Reactivity: Human
• Tag: N-6×His
• Form/Appearance: Powder
• Purity: 98%
• Conjugation: Unconjugated
• MW: 18.0 kDa
• Target: NME1
• Protein Sequence: AAH00293
• Source: Human NME1, His Tag (orb257714) is expressed from E.coli cells. It contains AA Ala 2 - Glu 152 (Accession # AAH00293).
• Expression System: E. coli
• Expression Region: Ala 2 - Glu 152
• Endotoxins: 1.0 EU per μg
• NCBI: AAH00293
• Storage: -20°C
• Buffer/Preservatives: PBS, pH7.4
• Alternative names: NME1,NDP kinase A,NDPA,GAAD,NM23-H1
• Note: For research use only
• Application notes: This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 18.0 kDa. The protein migrates as 17-18 kDa under reducing (R) condition (SDS-PAGE).
• Expiration Date: 6 months from date of receipt.

SDS-PAGE analysis of Human NME1 protein