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    Human NKG2A / CD159a Protein

    Human NKG2A / CD159a Protein

    Catalog Number: orb612126

    DispatchUsually dispatched within 5-10 working days
    $ 3,740.00
    Catalog Numberorb612126
    CategoryProteins
    DescriptionNKG2A/CD159a is a transmembrane protein belonging to the CD94/NKG2 family of C-type lectin-like receptors that inhibits innate immune system activation, also known as KLRC1, CD159a, NK cell receptor A and NKG2-A/NKG2-B type II integral membrane protein. NKG2A marks a unique immune effector subset preferentially co-expressing the tissue-resident CD103 molecule, but not immune checkpoint inhibitors. NKG2A blockade therapy operated through CD8 T cells, but not NK cells. The increase in NKG2A expression might be induced by IL-10, which was present at a high level in the plasma of HCC patients. Blocking IL-10 could specifically inhibit NKG2A expression in NK cells. These findings indicate that NKG2A expression is influenced by factors from cancer nests and contributes to NK cell exhaustion, suggesting that NKG2A blockade has the potential to restore immunity against liver tumors by reversing NK cell exhaustion.
    ReactivityHuman
    TagN-10×His
    Form/AppearancePowder
    Purity90%
    ConjugationUnconjugated
    MW17.9 kDa
    TargetNKG2A
    Protein SequenceNP_002250.1
    SourceHuman NKG2A, His Tag (orb612126) is expressed from human 293 cells (HEK293). It contains AA Pro 94 - Leu 233 (Accession # P26715-1).
    Expression SystemHEK293
    Expression RegionPro 94 - Leu 233
    Endotoxins1.0 EU per μg
    NCBINP_002250.1
    Storage-20℃
    Buffer/PreservativesPBS, pH7.4
    Alternative namesNKG2A,CD159a,KLRC1,NK cell receptor A
    Read more...
    NoteFor research use only
    Application notesThis protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 17.9 kDa. The protein migrates as 30-40 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
    Expiration Date6 months from date of receipt.
    • Human NKG2A / CD159a Protein [orb612109]

      Unconjugated

      95%

      42.5 kDa

      Human NKG2A, Fc Tag (orb612109) is expressed from human 293 cells (HEK293). It contains AA Pro 94 - Leu 233 (Accession # P26715-1).

      100 μg, 1 mg
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