Human Neuropilin-1 / NRP1 / CD304 Protein

• Catalog Number: orb257718
• Category: Proteins
• Description: Neuropilin-1 (NRP1) is also known as Vascular endothelial cell growth factor 165 receptor (VEGF165R), CD antigen CD304, which belongs to the neuropilin family. The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells.
• Reactivity: Human
• Tag: C-Fc
• Form/Appearance: Powder
• Purity: 95%
• Conjugation: Unconjugated
• MW: 96.5 kDa
• Target: Neuropilin-1
• Protein Sequence: AAH07533
• Source: Human NRP1, Fc Tag (orb257718) is expressed from human 293 cells (HEK293). It contains AA Phe 22 - Lys 644 (Accession # AAH07533).
• Expression System: HEK293
• Expression Region: Phe 22 - Lys 644
• Endotoxins: 1.0 EU per μg
• NCBI: AAH07533
• Storage: -20℃
• Buffer/Preservatives: Tris with Glycine, Arginine and NaCl, pH7.5
• Alternative names: NRP1,Neuropilin-1,NRP,VEGF165R,CD304
• Note: For research use only
• Application notes: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 96.5 kDa. The protein migrates as 105-130 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.

References

Kerros, Celine et al. Neuropilin-1 mediates neutrophil elastase uptake and cross-presentation in breast cancer cells J Biol Chem, 292, 10295-10305 (2017)

PubMed: 28468826

SDS-PAGE analysis of Human Neuropilin-1 protein