Human Nectin-1 / PVRL1 / CD111 Protein

• Catalog Number: orb257789
• Category: Proteins
• Description: Poliovirus receptor-related protein 1 (PVRL1) is also known as Herpes virus entry mediator C (HveC), Herpesvirus Ig-like receptor (HIgR), Nectin-1, CD antigen CD111, PVRL1 / Nectin-1 / CD111 belongs to the nectin family. PVRL1 / Nectin-1 is a membrane protein with three extracellular immunoglobulin domains, a single transmembrane helix and a cytoplasmic tail. The protein can mediate Ca2+-independent cellular adhesion further characterizing it as IgSF cell adhesion molecule (IgSF CAM). PVRL1 is adhesion molecule found in a wide range of tissues. PVRL1 / Nectin-1 promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between PVRL1/nectin-1 and PVRL3/nectin-3 and between PVRL1/nectin-1 and PVRL4/nectin-4.
• Reactivity: Human
• Tag: C-8×His
• Form/Appearance: Powder
• Purity: 95%
• Conjugation: Unconjugated
• MW: 35.0 kDa
• Target: Nectin-1
• Protein Sequence: NP_002846
• Source: Human Nectin-1, His Tag (orb257789) is expressed from human 293 cells (HEK293). It contains AA Gln 31 - Thr 334 (Accession # NP_002846).
• Expression System: HEK293
• Expression Region: Gln 31 - Thr 334
• Endotoxins: 1.0 EU per μg
• NCBI: NP_002846
• Storage: -20℃
• Buffer/Preservatives: PBS, pH7.4
• Alternative names: PVRL1,Nectin-1,CD111,CLPED1,ED4,HIgR,HVEC,OFC7,PRR
• Note: For research use only
• Application notes: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 35.0 kDa. The protein migrates as 45-60 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.

SDS-PAGE analysis of Human Nectin-1 protein