Human MIS RII Protein, Mouse IgG2a Fc Tag

• Catalog Number: orb1909750
• Category: Proteins
• Description: MIS RII (Mullerian inhibiting substance type II receptor), also known as AMHRII (anti-Mullerian hormone type II receptor), is a serine/threonine receptor with a single transmembrane domain that belongs to the family of type II receptors of the TGF-beta superfamily. Mutations in MIS RII result in persistent Mullerian duct syndrome (PMDS), persistent Müllerian duct syndrome (PMDS) is a sex-limited disorder in which males develop portions of the female reproductive tract. Anti-Müllerian hormone (AMH) and its receptor (AMHR2) induce the regression of the Müllerian ducts in male embryos, but the mechanism by which the Amhr2 gene is specifically activated is not fully understood.
• Reactivity: Human
• Tag: C-mFc2(mIgG2a)
• Form/Appearance: Powder
• Purity: 90%
• Conjugation: Unconjugated
• MW: 40.4 kDa
• Target: MIS RII
• Source: Human MIS RII Protein, Mouse IgG2a Fc Tag is expressed from human 293 cells (HEK293). It contains AA Pro 18 - Ser 144 (Accession # Q16671-1).
• Expression System: HEK293
• Expression Region: Pro 18 - Ser 144
• Endotoxins: 0.1 EU per μg
• Storage: -20°C
• Buffer/Preservatives: PBS, pH 7.4
• Note: For research use only
• Application notes: This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 40.4 kDa. The protein migrates as 48-55 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.