Human MBL Protein

• Catalog Number: orb257684
• Category: Proteins
• Description: Mannose-binding lectin (MBL) is also known as mannose-binding protein, mannan-binding protein (MBP), Mannose-binding protein C, Collectin-1 (COLEC1), MBL2, which belongs to the class of collectins in the C-type lectin superfamily. MBL contains one C-type lectin domain and one collagen-like domain. MBL has an oligomeric structure (400-700 kDa), built of subunits that contain three presumably identical peptide chains of about 30 kDa each. MBL is calcium-dependent lectin involved in innate immune defense. MBL binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. MBL binds to late apoptotic cells. MBL may bind D.
• Reactivity: Human
• Tag: C-7×His
• Form/Appearance: Powder
• Purity: 95%
• Conjugation: Unconjugated
• MW: 25.9 kDa
• Target: MBL
• Source: Human MBL, His Tag (orb257684) is expressed from human 293 cells (HEK293). It contains AA Glu 21 - Ile 248 (Accession # P11226-1).
• Expression System: HEK293
• Expression Region: Glu 21 - Ile 248
• Endotoxins: 1.0 EU per μg
• NCBI: AAH96179
• Storage: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
• Buffer/Preservatives: PBS, pH7.4
• Alternative names: MBL,MBL2,MBP1,MBP-C,Collectin-1,COLEC1,HSMBPC,MBL2
• Note: For research use only
• Application notes: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 25.9 kDa. The protein migrates as 30-38 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.

SDS-PAGE analysis of Human MBL protein