Human Latent TGF-beta 3 / Latent TGFB3 Protein

• Catalog Number: orb867322
• Category: Proteins
• Description: Transforming growth factor beta 3 ( TGFB3) is also known as TGF-β3, is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development. TGF-beta 3 is similar with TGF-beta 1 and ­-beta 2, act as cellular switches to regulate immune function, cell proliferation, and epithelial­-mesenchymal transition. TGF-beta-3 is released from LAP by integrins: integrin-binding results in distortion of the LAP chain and subsequent release of the active TGF-beta-3. Once activated following release of LAP, TGF-beta-3 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal.
• Reactivity: Human
• Tag: N-10×His
• Form/Appearance: Powder
• Purity: 90%
• Conjugation: Unconjugated
• MW: 46.8 kDa
• Target: TGF-beta 3
• Protein Sequence: NP_003230.1
• Source: Human Latent TGF-beta 3, His Tag (orb867322) is expressed from human 293 cells (HEK293). It contains AA Leu 24 - Ser 412 (Accession # P10600-1).
• Expression System: HEK293
• Expression Region: Leu 24 - Ser 412
• Endotoxins: 1.0 EU per μg
• NCBI: NP_003230.1
• Storage: -20℃
• Buffer/Preservatives: PBS, pH7.4
• Alternative names: TGFB3,ARVD,TGF-beta3
• Note: For research use only
• Application notes: This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 46.8 kDa. The protein migrates as 44-47 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.