Human Latent GDF-2 / BMP-9 Protein

• Catalog Number: orb762433
• Category: Proteins
• Description: Human Growth and differentiation factor 2 (GDF-2), also known as Bone morphogenetic protein 9 (BMP-9), is a member of the BMP subgroup of the TGF-beta superfamily proteins that signal through heterodimeric complexes composed of type I and type II BMP receptors. GDF-2 Potent circulating inhibitor of angiogenesis. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG. ALK1 is a signalling receptor for bone morphogenetic protein-9 (BMP-9) in endothelial cells (ECs). BMP-9 bound with high affinity to ALK1 and endoglin, and weakly to the type-I receptor ALK2 and to the BMP type-II receptor (BMPR-II) and activin type-II receptor (ActR-II) in transfected COS cells. Binding of BMP-9 to ALK2 was greatly facilitated when BMPR-II or ActR-II were co-expressed.
• Reactivity: Human
• Tag: N-10×His
• Form/Appearance: Powder
• Purity: 95%
• Conjugation: Unconjugated
• MW: 47.0 kDa
• Target: Latent GDF-2
• Source: Human Latent GDF-2, His Tag (orb762433) is expressed from human 293 cells (HEK293). It contains AA Lys 23 - Arg 429 (Accession # Q9UK05-1).
• Expression System: HEK293
• Expression Region: Lys 23 - Arg 429
• Endotoxins: 1.0 EU per μg
• Storage: -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. After reconstitution, this product is stable after storage at -20°C or lower.
• Buffer/Preservatives: PBS, pH7.4
• Alternative names: Latent GDF-2,Latent GDF2,Latent BMP-9,Latent BMP9
• Note: For research use only
• Application notes: This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 47.0 kDa. The protein migrates as 13 kDa and 40-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.