Human Laminin 211 Protein, premium grade

• Catalog Number: orb1786191
• Category: Proteins
• Description: Laminin-α2 is a critical component of the laminin heterotrimer, which along with laminin-β1 or β2 and laminin-γ1 form the structural glycoproteins laminin-211 and laminin-221 in skeletal muscle. Laminin-211 is the most abundant laminin isoform in the basement membrane of adult skeletal muscle. Laminin-211 and -221 polymerize with each other and interact with nidogen and collagen-IV to form the muscle basal lamina. Laminin-211 and laminin-221 bind to muscle cell surface through the α7β1 integrin and α-dystroglycan of the dystrophin glycoprotein complex via their globular C-terminal domains.
• Reactivity: Human
• Tag: N-Fc
• Form/Appearance: Powder
• Purity: 90%
• Conjugation: Unconjugated
• MW: 94.3 kDa & 35 kDa & 35.7 kDa
• Target: Laminin 211
• Source: Human Laminin 211 E8 Protein, Fc Tag (orb1786191) is expressed from human 293 cells (HEK293). It contains AA Leu 1900 - Ala 2722 & Asp 1714 - Leu 1786 & Asp 1528 - Pro 1609 (Accession # P24043 & P07942 & P11047).
• Expression System: HEK293
• Biological Activity: Immobilized Human Laminin 211 E8 Protein, Fc Tag at 5 μg/mL (100 μL/well) can bind Human ITGA7X2B&ITGB1 Heterodimer Protein, His Tag&Tag Free with a linear range of 0.02-0.313 μg/mL (QC tested).
• Expression Region: Leu 1900 - Ala 2722 & Asp 1714 - Leu 1786 & Asp 1528 - Pro 1609
• Endotoxins: 1.0 EU per μg
• Storage: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
• Buffer/Preservatives: PBS, pH 7.4
• Note: For research use only
• Application notes: This protein .
• Expiration Date: 6 months from date of receipt.

Immobilized Human Laminin 211 E8 Protein, Fc Tag (Cat. No. orb1786191) at 5 μg/mL (100 μL/well) can bind Human ITGA7X2B & ITGB1 Heterodimer Protein, His Tag & Tag Free with a linear range of 0.02-0.313 μg/mL (QC tested).