Human KLRG1 Protein

Catalog Number: orb1184764

Catalog Number	orb1184764
Category	Proteins
Description	The co-inhibitory receptor killer-cell lectin like receptor G1 (KLRG1) is specifically expressed on NK cells and activated CD8+ T-cells and has been postulated to be a marker of senescence. KLRG1+ T cells are a major reason of chronic tissue damage in some autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. In tumors, tumor cells which express E-cadherin or N-cadherin bind to KLRG1 and inhibit the antitumor activity of T and NK cells. Thus, KLRG1 acts as an immunocheckpoint inhibitory receptor.
Reactivity	Human
Tag	N-10×His
Form/Appearance	Powder
Purity	90%
Conjugation	Unconjugated
MW	17.4 kDa
Target	KLRG1
Protein Sequence	NP_001316028.1
Source	Human KLRG1, His Tag (orb1184764) is expressed from human 293 cells (HEK293). It contains AA Leu 60 - Phe 195 (Accession # Q96E93-1).
Expression System	HEK293
Expression Region	Leu 60 - Phe 195
Endotoxins	1.0 EU per μg
NCBI	NP_001316028.1
Storage	-20℃
Buffer/Preservatives	PBS, pH7.4
Alternative names	KLRG1 Read more...
Note	For research use only
Application notes	This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 17.4 kDa. The protein migrates as 30-42 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Expiration Date	6 months from date of receipt.

Conjugation:	Unconjugated
Purity:	The purity of the protein is greater than 90% as determined by SDS-PAGE and Coomassie blue staining.
MW:	The protein has a predicted molecular mass of 41.6 kDa after removal of the signal peptide.The apparent molecular mass of hFc-KLRG1 is approximately 55-70 kDa due to glycosylation.
Source:	Mammalian

Sizes Available: 50 μg, 10 μg, 100 μg

Purity:	Greater than 90% as determined by SDS-PAGE.
MW:	31.5 kDa
Source:	E.coli

Purity:	98.00%
MW:	The protein has a predicted MW of 42.8 kDa. Due to glycosylation, the protein migrates to 50-65 kDa based on Tris-Bis PAGE result.