Human KIR2DL4 / CD158d Protein

• Catalog Number: orb1152439
• Category: Proteins
• Description: Killer cell immunoglobulin-like receptor 2DL4(KIR2DL4), which belongs to the immunoglobulin superfamily, is an inhibitory receptor of NK cells. Soluble HLA-G binds to KIR2DL4 in endosomes and activates the pathway of DNA-PKcs (DNA-dependent protein kinase, catalytic subunit)-AKT-NF-κB signals. The stimulation of the ITIM of KIR2DL4 protein brings about the recruitment and activation of non-receptor protein phosphatases Src homology 2 domain-containing tyrosine phosphatase (SHP)-1 and SHP-2, and the following inhibition of CD16/FcγRIIIa signaling pathway in human NK cells.
• Reactivity: Human
• Tag: C-Fc
• Form/Appearance: Powder
• Purity: 90%
• Conjugation: Unconjugated
• MW: 50.5 kDa
• Target: KIR2DL4
• Protein Sequence: NP_002246.5
• Source: Human KIR2DL4, Fc Tag (orb1152439) is expressed from human 293 cells (HEK293). It contains AA His 24 - His 242 (Accession # Q99706-1).
• Expression System: HEK293
• Expression Region: His 24 - His 242
• Endotoxins: 1.0 EU per μg
• NCBI: NP_002246.5
• Storage: -20℃
• Buffer/Preservatives: 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
• Alternative names: CD158d
• Note: For research use only
• Application notes: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 50.5 kDa. The protein migrates as 55-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.