Human Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein, His Tag&Tag Free (MALS verified)

• Catalog Number: orb1939664
• Category: Proteins
• Description: Integrin alpha 4 beta 7 is an integrin family adhesion receptor that shares subunits with alpha 4 beta 1 (VLA4) and the E-Cadherin receptor, alpha E beta 7 . Integrin alpha 4 beta 7, which is critical for homing to intestinal mucosa, is induced during T cell activation in Peyer’s patches or mesenteric lymph nodes.Its expression requires signals from local dendritic and stromal cells, including secreted retinoic acid. The HIV-1 envelope protein gp120 binds to the active form of Integrin alpha 4 beta 7, and this may or may not account for the concentration of HIV-1 virus in the gut-associated lymphoid tissue (GALT). Integrin alpha 4 beta 7 may also be involved in lymphocyte trafficking in acute intestinal graft vs. host disease (GVHD).
• Reactivity: Human
• Tag: C-6×His | Native
• Form/Appearance: Powder
• Purity: 90%
• Conjugation: AP
• MW: 59.5 kDa & 59.4 kDa
• Target: Integrin alpha 4 beta 7
• Source: Human ITGA4&ITGB7 Heterodimer Protein, His Tag&Tag Free (IT7-H52W5) is expressed from human 293 cells (HEK293). It contains AA Tyr 34 - Arg 620 & Glu 20 - Pro 521 (Accession # P13612-1 & P26010-1).
• Expression System: HEK293
• Expression Region: Tyr 34 - Arg 620 & Glu 20 - Pro 521
• Endotoxins: 1.0 EU per μg
• Storage: -20°C
• Buffer/Preservatives: 50 mM Tris, 150 mM NaCl, pH 8.0
• Note: For research use only
• Application notes: Human ITGA4&ITGB7 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGA4 and ITGB7, has a calculated MW of 59.5 kDa (ITGA4) & 59.4 kDa (ITGB7). The protein migrates as 75-95 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.