Human IL-37 / IL-1F7 Protein

• Catalog Number: orb1146980
• Category: Proteins
• Description: Interleukin-1 family member 7 (IL1F7b) ,a member of the IL-1 family, is aslo known as interleukin-37, interleukin-1 homolog 4 (IL-1H4), interleukin-1 zeta (IL-1 zeta) and interleukin-1-related protein, which can interact with SMAD3 and bind to IL18R1, but not to IL1R1, with lower affinity than IL18. IL1F7b is a suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Therefore,IL1F7b can suppress, or reduce, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spare anti-inflammatory cytokines. Furthermore,IL1F7b can also inhibit dendritic cell activation.
• Reactivity: Human
• Tag: C-10×His
• Form/Appearance: Powder
• Purity: 95%
• Conjugation: Unconjugated
• MW: 20.1 kDa
• Target: IL-37
• Source: Human IL-37, His Tag (orb1146980) is expressed from E. coli cells. It contains AA Lys 27 - Asp 192 (Accession # Q9NZH6-2).
• Expression System: E. coli
• Expression Region: Lys 27 - Asp 192
• Endotoxins: 1.0 EU per μg
• NCBI: NP_775297.1
• Storage: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
• Buffer/Preservatives: PBS, 1 mM TCEP, pH7.4
• Alternative names: IL1F7,IL37,FIL1Z,IL1H4,IL1RP1
• Note: For research use only
• Application notes: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 20.1 kDa. The protein migrates as 20-23 kDa under reducing (R) condition (SDS-PAGE).
• Expiration Date: 6 months from date of receipt.