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Human IL-36 beta (157a.a.) protein
Catalog Number: orb107766
| Catalog Number | orb107766 |
|---|---|
| Category | Proteins |
| Description | Interleukin-36 (IL-36) is a pro-inflammatory cytokine which plays an important role in the pathophysiology of several diseases.IL-36F, IL-36=, and IL-36G (formerly IL-1F6, IL-1F8, and IL-1F9) are IL-1 family members that signal through the IL-1 receptorfamily members IL-1Rrp2 (IL-1RL2) and IL-1RAcP. IL-36 beta is reported to be expressed at higher levels in psoriatic plaquesthan in symptomless psoriatic skin or healthy control skin. Furthermore, it can stimulate production of interleukin-6 andinterleukin-8 in synovial fibroblasts, articular chondrocytes and mature adipocytes. Two alternatively spliced transcript variantsencode distinct (164 or 157 residues) protein isoforms that differ in their C-terminal 70 amino acid residues have been reportedand IL-36= isoform 2 is synthesized as a 157 a.a. protein. Specifically, human IL-36= shares low sequence identity with IL-1=, IL-36RA, IL-36F and IL-36G. |
| Target | IL-36 beta |
| Conjugation | Unconjugated |
| Buffer/Preservatives | Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4. |
| Purity | > 97 % by SDS-PAGE and HPLC analyses |
| Protein Sequence | MNPQREAAPK SYAIRDSRQM VWVLSGNSLI AAPLSRSIKP VTLHLIACRD TEFSDKEKGNMVYLGIKGKD LCLFCAEIQG KPTLQLKEKN IMDLYVEKKA QKPFLFFHNK EGSTSVFQSVSYPGWFIATS TTSGQPIFLT KERGITNNTN FYLDSVE |
| MW | 17.7kDa |
| Tested applications | HPLC, SDS-PAGE |
| Biological Origin | E.coli |
| Storage | Store at 4°C for up to two weeks. For long term storage, aliquot and store at -20°C, avoid freeze/thaw cycles. |
| Alternative names | Human Interleukin-36 beta protein |
| Note | For research use only |
SDS-PAGE analysis of Human IL-36 beta (157a.a.) protein
