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Human IL-36 beta (157a.a.) protein

Catalog Number: orb107766

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$ 340.00
Catalog Numberorb107766
CategoryProteins
DescriptionInterleukin-36 (IL-36) is a pro-inflammatory cytokine which plays an important role in the pathophysiology of several diseases.IL-36F, IL-36=, and IL-36G (formerly IL-1F6, IL-1F8, and IL-1F9) are IL-1 family members that signal through the IL-1 receptorfamily members IL-1Rrp2 (IL-1RL2) and IL-1RAcP. IL-36 beta is reported to be expressed at higher levels in psoriatic plaquesthan in symptomless psoriatic skin or healthy control skin. Furthermore, it can stimulate production of interleukin-6 andinterleukin-8 in synovial fibroblasts, articular chondrocytes and mature adipocytes. Two alternatively spliced transcript variantsencode distinct (164 or 157 residues) protein isoforms that differ in their C-terminal 70 amino acid residues have been reportedand IL-36= isoform 2 is synthesized as a 157 a.a. protein. Specifically, human IL-36= shares low sequence identity with IL-1=, IL-36RA, IL-36F and IL-36G.
Tested applicationsHPLC, SDS-PAGE
Purity> 97 % by SDS-PAGE and HPLC analyses
ConjugationUnconjugated
MW17.7kDa
TargetIL-36 beta
Protein SequenceMNPQREAAPK SYAIRDSRQM VWVLSGNSLI AAPLSRSIKP VTLHLIACRD TEFSDKEKGNMVYLGIKGKD LCLFCAEIQG KPTLQLKEKN IMDLYVEKKA QKPFLFFHNK EGSTSVFQSVSYPGWFIATS TTSGQPIFLT KERGITNNTN FYLDSVE
Biological OriginE.coli
StorageStore at 4°C for up to two weeks. For long term storage, aliquot and store at -20°C, avoid freeze/thaw cycles.
Buffer/PreservativesLyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.
Alternative namesHuman Interleukin-36 beta protein
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NoteFor research use only
Expiration Date6 months from date of receipt.
Human IL-36 beta (157a.a.) protein

SDS-PAGE analysis of Human IL-36 beta (157a.a.) protein