Human IL-36 beta (157a.a.) protein

• Catalog Number: orb107766
• Category: Proteins
• Description: Interleukin-36 (IL-36) is a pro-inflammatory cytokine which plays an important role in the pathophysiology of several diseases.IL-36F, IL-36=, and IL-36G (formerly IL-1F6, IL-1F8, and IL-1F9) are IL-1 family members that signal through the IL-1 receptorfamily members IL-1Rrp2 (IL-1RL2) and IL-1RAcP. IL-36 beta is reported to be expressed at higher levels in psoriatic plaquesthan in symptomless psoriatic skin or healthy control skin. Furthermore, it can stimulate production of interleukin-6 andinterleukin-8 in synovial fibroblasts, articular chondrocytes and mature adipocytes. Two alternatively spliced transcript variantsencode distinct (164 or 157 residues) protein isoforms that differ in their C-terminal 70 amino acid residues have been reportedand IL-36= isoform 2 is synthesized as a 157 a.a. protein. Specifically, human IL-36= shares low sequence identity with IL-1=, IL-36RA, IL-36F and IL-36G.
• Tested applications: HPLC, SDS-PAGE
• Purity: > 97 % by SDS-PAGE and HPLC analyses
• Conjugation: Unconjugated
• MW: 17.7kDa
• Target: IL-36 beta
• Protein Sequence: MNPQREAAPK SYAIRDSRQM VWVLSGNSLI AAPLSRSIKP VTLHLIACRD TEFSDKEKGNMVYLGIKGKD LCLFCAEIQG KPTLQLKEKN IMDLYVEKKA QKPFLFFHNK EGSTSVFQSVSYPGWFIATS TTSGQPIFLT KERGITNNTN FYLDSVE
• Storage: Store at 4°C for up to two weeks. For long term storage, aliquot and store at -20°C, avoid freeze/thaw cycles.
• Buffer/Preservatives: Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.
• Alternative names: Human Interleukin-36 beta protein
• Note: For research use only
• Expiration Date: 6 months from date of receipt.

SDS-PAGE analysis of Human IL-36 beta (157a.a.) protein