Human IL-36 alpha (153a.a.) protein

• Catalog Number: orb107763
• Category: Proteins
• Description: Interleukin-36 (IL-36) is a pro-inflammatory cytokine which plays an important role in the pathophysiology of several diseases.IL-36C, IL-36F, and IL-36G (formerly IL-1F6, IL-1F8, and IL-1F9) are IL-1 family members that signal through the IL-1 receptorfamily members IL-1Rrp2 (IL-1RL2) and IL-1RAcP. Studies showed IL-36C is mainly found in skin and lymphoid tissues, butalso in fetal brain, trachea, stomach and intestine. Notably, IL-36 alpha is the only novel IL-1 family member expressed on Tcells.Recombinant human interleukin-36 alpha (153 a.a.) contains 153 amino acids residues which is a single non-glycosylatedpolypeptide and it shares 57 - 68% a.a. sequence identity with mouse, rabbit, equine and bovine IL-36C and 27 - 57% a.a.sequence identity with other novel IL-1 family members.
• Tested applications: HPLC, SDS-PAGE
• Purity: > 95 % by SDS-PAGE and HPLC analyses
• Conjugation: Unconjugated
• MW: 17.1 kDa
• Target: IL-36 alpha
• Protein Sequence: KIDTPQQGSI QDINHRVWVL QDQTLIAVPR KDRMSPVTIA LISCRHVETL EKDRGNPIYLGLNGLNLCLM CAKVGDQPTL QLKEKDIMDL YNQPEPVKSF LFYHSQSGRN STFESVAFPGWFIAVSSEGG CPLILTQELG KANTTDFGLT MLF
• Storage: Store at 4°C for up to two weeks. For long term storage, aliquot and store at -20°C, avoid freeze/thaw cycles.
• Buffer/Preservatives: Lyophilized from a 0.2 μm filtered concentrated solution in 20 mM Tris, 300 mM NaCl, pH 8.0, 0.1 % Tween 80.
• Alternative names: Human Interleukin-36 alpha protein
• Note: For research use only
• Expiration Date: 6 months from date of receipt.