Human IL-28 R alpha / IFN-lambda R1 Protein

• Catalog Number: orb1184778
• Category: Proteins
• Description: IL-28 R alpha (Interleukin-28 receptor subunit alpha) also known as IFNLR1 (IFN-lambda receptor 1), it heterodimerizes with another subunit, IL-10RB, to form a type II cytokine receptor ,which binds IL-28A, IL-28B and IL-29. These ligands, which are distantly related to class I in terferons, are activated upon viral infection and trigger the JAK-STAT signaling pathway to exert antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts.
• Reactivity: Human
• Tag: C-10×His
• Form/Appearance: Powder
• Purity: 95%
• Conjugation: Unconjugated
• MW: 25.5 kDa
• Target: IL-28 R alpha
• Source: Human IL-28 R alpha, His Tag (orb1184778) is expressed from human 293 cells (HEK293). It contains AA Arg 21 - Ala 228 (Accession # Q8IU57-1).
• Expression System: HEK293
• Expression Region: Arg 21 - Ala 228
• Endotoxins: 1.0 EU per μg
• NCBI: NP_734464.1
• Storage: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
• Buffer/Preservatives: PBS, pH7.4
• Alternative names: Interferon lambda receptor 1,IFN-lambda receptor 1
• Note: For research use only
• Application notes: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 25.5 kDa. The protein migrates as 40-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.