Human IL-24 Protein(BLI verified)

• Catalog Number: orb1496282
• Category: Proteins
• Description: Interleukin-24 (IL-24, also known as melanoma differentiation-associated gene-7) belongs to the family of IL-10-related cytokines, which includes IL-10, -19, -20, -22, -24 and -26. Interleukin 24 signals through two heterodimeric receptors: IL-20R1/IL-20R2 and IL-22R1/IL-20R2. Upon binding to its receptors, IL-24 induces rapid activation of Stat-1 and Stat-3 transcription factors, which appear to play a role in cell survival and proliferation . Structurally and functionally, IL-24 is highly conserved across species.IL-24 has been shown to possess cancer-specific apoptosis-inducing activity, and has therefore been suggested as a potential anti-cancer agent.
• Reactivity: Human
• Tag: C-10×His
• Form/Appearance: Powder
• Purity: 90%
• Conjugation: Unconjugated
• MW: 20.0 kDa
• Target: IL-24
• Source: Human IL-24 Protein, His Tag (orb1496282) is expressed from human 293 cells (HEK293). It contains AA Gln 52 - Leu 206 (Accession # Q13007-1).
• Expression System: HEK293
• Biological Activity: Loaded Human IL-22 R alpha 1 Protein, Fc Tag on Protein A Biosensor, can bind Human IL-24 Protein, His Tag with an affinity constant of 1.71 μM as determined in BLI assay (ForteBio Octet Red96e) (QC tested).
• Expression Region: Gln 52 - Leu 206
• Endotoxins: 1.0 EU per μg
• Storage: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
• Buffer/Preservatives: PBS, pH7.4
• Alternative names: Interleukin-24,IL-24,Melanoma differentiation-asso
• Note: For research use only
• Application notes: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 20.0 kDa. The protein migrates as 30-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.

Loaded Human IL-22 R alpha 1 Protein, Fc Tag (Cat. No. orb1289953) on Protein A Biosensor, can bind Human IL-24 Protein, His Tag (Cat. No. orb1496282) with an affinity constant of 1.71 μM as determined in BLI assay (ForteBio Octet Red96e) (QC tested).