Human IL-15 R alpha / CD215 Protein

• Catalog Number: orb570279
• Category: Proteins
• Description: IL15R is a heterotrimer of IL15RA, IL2RB and IL2RG. IL-15RA, also known as CD215, IL-15 R alpha, is a widely expressed 60 kDa transmembrane glycoprotein. High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Expression of different isoforms may alter or interfere with signal transduction. An interleukin (IL)-15 superagonist/IL-15 receptor α fusion complex (IL-15SA/IL-15RA; ALT-803) activates the IL-15 receptor on CD8 T cells and NK cells, and has shown significant anti-tumor. Signal transduction involves SYK. Higher levels of soluble sIL-15RA form in comparison with membrane-bound forms is present in all brain structures.
• Reactivity: Human
• Tag: C-Fc
• Form/Appearance: Powder
• Purity: 95%
• Conjugation: Unconjugated
• MW: 44.8 kDa
• Target: IL-15 R alpha
• Source: Human IL-15 R alpha, Fc Tag (orb570279) is expressed from human 293 cells (HEK293). It contains AA Ile 31 - Thr 205 (Accession # Q13261-1).
• Expression System: HEK293
• Biological Activity: Immobilized Human IL-15 R alpha, Fc Tag at 2 μg/mL (100 μL/well) can bind Biotinylated Human IL-15, Fc, with a linear range of 1-31 ng/mL (QC tested).
• Expression Region: Ile 31 - Thr 205
• Endotoxins: 1.0 EU per μg
• NCBI: NP_002180.1
• Storage: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
• Buffer/Preservatives: PBS, pH7.4
• Alternative names: IL-15 R alpha,CD215,IL15RA,IL-15RA,IL-15R-alpha
• Note: For research use only
• Application notes: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 44.8 kDa. The protein migrates as 58-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.

Immobilized Human IL-15 R alpha, Fc Tag (Cat. No. orb570279) at 2 μg/mL (100 μL/well) can bind Biotinylated Human IL-15, Fc, Avitag with a linear range of 1-31 ng/mL (QC tested).