Human GITR / TNFRSF18 Protein

• Catalog Number: orb257508
• Category: Proteins
• Description: Glucocorticoid-induced TNFR-related protein (GITR) is also known as Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), activation-inducible TNFR family receptor (AITR), CD antigen CD357, which is a member of the tumor necrosis factor receptor (TNF-R) superfamily. GITR is receptor for TNFSF18, which seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR also mediated NF-kappa-B activation via the TRAF2/NIK pathway.
• Reactivity: Human
• Tag: C-6×His
• Form/Appearance: Powder
• Purity: 92%
• Conjugation: Unconjugated
• MW: 16.4 kDa
• Target: GITR
• Protein Sequence: Gln 26 - Glu 161
• Source: Human GITR, His Tag (orb257508) is expressed from human 293 cells (HEK293). It contains AA Gln 26 - Glu 161 (Accession # Q9Y5U5-1).
• Expression System: HEK293
• Expression Region: Gln 26 - Glu 161
• Endotoxins: 1.0 EU per μg
• Storage: -20℃
• Buffer/Preservatives: PBS, pH7.4
• Alternative names: AITR,GITR,TNFRSF18,CD357
• Note: For research use only
• Application notes: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 16.4 kDa. The protein migrates as 20-25 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.

SDS-PAGE analysis of Human GITR protein

Line graph illustrates about the sensitivity range of Human GITR protein using different concentrations