Human Frizzled-5 / FZD5 Protein

• Catalog Number: orb257489
• Category: Proteins
• Description: Frizzled-5 (FZD5) is also known as FzE5, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD5 contains one FZ (frizzled) domain. FZD5 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. FZD5 interacts specifically with Wnt5A to induce the beta-catenin pathway. FZD5 interacts with GOPC.
• Reactivity: Human
• Tag: C-Fc
• Form/Appearance: Powder
• Purity: 95%
• Conjugation: Unconjugated
• MW: 42.6 kDa
• Target: Frizzled-5
• Protein Sequence: Q13467
• Source: Human Frizzled-5, Fc Tag (orb257489) is expressed from human 293 cells (HEK293). It contains AA Ala 27 - Pro 167 (Accession # Q13467).
• Expression System: HEK293
• Expression Region: Ala 27 - Pro 167
• Endotoxins: 1.0 EU per μg
• NCBI: Q13467
• Storage: -20℃
• Buffer/Preservatives: PBS, pH7.4
• Alternative names: FZD5,Frizzled-5,C2orf31,,Fz-5,hFz5,FzE5
• Note: For research use only
• Application notes: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 42.6 kDa. The protein migrates as 50-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.

SDS-PAGE analysis of Human Frizzled-5 protein