Human Frizzled-4 / FZD4 Protein

• Catalog Number: orb257488
• Category: Proteins
• Description: Frizzled-4 (FZD4) is also known as FzE4, CD344, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD4 contains one FZ (frizzled) domain. FZD4 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. FZD4 interacts with MAGI3 and norrin (NDP).
• Reactivity: Human
• Tag: C-Fc
• Form/Appearance: Powder
• Purity: 95%
• Conjugation: Unconjugated
• MW: 42.9 kDa
• Target: Frizzled-4
• Protein Sequence: AAI14528
• Source: Human Frizzled-4, Fc Tag (orb257488) is expressed from human 293 cells (HEK293). It contains AA Phe 37 - Glu 180 (Accession # AAI14528).
• Expression System: HEK293
• Expression Region: Phe 37 - Glu 180
• Endotoxins: 1.0 EU per μg
• NCBI: AAI14528
• Storage: -20℃
• Buffer/Preservatives: PBS, pH7.4
• Alternative names: FZD4,Frizzled-4,CD344,Fz-4,hFz4,FzE4
• Note: For research use only
• Application notes: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 42.9 kDa. The protein migrates as 50-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.

SDS-PAGE analysis of Human Frizzled-4 protein