Human FKBP12 / FKBP1A Protein

• Catalog Number: orb257947
• Category: Proteins
• Description: Peptidyl-prolyl cis-trans isomerase FKBP1A, a member of the FKBP-type PPIase family and FKBP1 subfamily, is also known as FK506-binding protein 1A, immunophilin FKBP12 and 12 kDa FK506-binding protein, which contains one PPIase FKBP-type domain. FKBP1A is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 (tacrolimus) and rapamycin (sirolimus).FKBP1A interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. FKBP1A can also interact with multiple intracellular calcium release channels including the tetrameric skeletal muscle ryanodine receptor. Furthermore, FKBP1A can recruite SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal.
• Reactivity: Human
• Tag: C-6×His
• Form/Appearance: Powder
• Purity: 95%
• Conjugation: Unconjugated
• MW: 12.8 kDa
• Target: FKBP12
• Protein Sequence: NP_000792.1
• Source: Human FKBP12, His Tag (orb257947) is expressed from E.coli cells. It contains AA Met 1 - Glu 108 (Accession # P62942-1).
• Expression System: E. coli
• Expression Region: Met 1 - Glu 108
• Endotoxins: 1.0 EU per μg
• NCBI: NP_000792.1
• Storage: -20℃
• Buffer/Preservatives: 50 mM HEPES, 150 mM NaCl, pH7.5
• Alternative names: FKBP1A,FKBP1,Calstabin-1,FKBP12,Rotamase,PKC12,PPI
• Note: For research use only
• Application notes: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 12.8 kDa. The protein migrates as 13 kDa under reducing (R) condition (SDS-PAGE).
• Expiration Date: 6 months from date of receipt.

SDS-PAGE analysis of Human FKBP12 protein