Human Fetuin A / FETUA Protein

• Catalog Number: orb257467
• Category: Proteins
• Description: Alpha-2-HS-glycoprotein (AHSG) is also known as Alpha-2-Z-globulin, Ba-alpha-2-glycoprotein, Fetuin-A (FETUA), is a glycoprotein that is composed of two subunits, the A and B chains, belongs to the cystatin family of proteases inhibitors and the fetuin class of plasma binding proteins. AHSG / Fetuin A is highly expressed in embryonic cells and adult hepatocytes, and is expressed to a lesser extent in monocytes/macrophages. Fetuins are carrier proteins like albumin. Fetuin-A / AHSG forms soluble complexes with calcium and phosphate and thus is a carrier of otherwise insoluble calcium phosphate. Thus AHSG / Fetuin A is a potent inhibitor of pathological calcification. Fetuin A / FETUA promotes phagocytosis of apoptotic cells and plays a role in bone development, calcium homeostasis and insulin sensitivity. Mice deficient in Fetuin-A show systemic calcification of soft tissues.
• Reactivity: Human
• Tag: C-6×His
• Form/Appearance: Powder
• Purity: 98%
• Conjugation: Unconjugated
• MW: 38.2 kDa
• Target: Fetuin A
• Protein Sequence: NP_001613.2
• Source: Human Fetuin A, His Tag (orb257467) is expressed from human 293 cells (HEK293). It contains AA Ala 19 - Val 367 (Accession # P02765-1).
• Expression System: HEK293
• Expression Region: Ala 19 - Val 367
• Endotoxins: 1.0 EU per μg
• NCBI: NP_001613.2
• Storage: -20℃
• Buffer/Preservatives: PBS, pH7.4
• Alternative names: AHSG,FETUA,Fetuin A
• Note: For research use only
• Application notes: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 38.2 kDa. The protein migrates as 45-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.

SDS-PAGE analysis of Human Fetuin A protein